London Cancer New Drugs Group Rapid Review
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چکیده
Abraxane is licensed as monotherapy for the treatment of metastatic breast cancer in patients who have failed first-line treatment for metastatic disease and for who standard, anthracycline containing therapy is not indicated. The licensed dose for this indication is 260mg/m every 3 weeks. The substitution of paclitaxel/docetaxel for Abraxane will, in the majority of cases, result in Abraxane being used off-label. In addition, it is not clear what the weekly dose of Abraxane would be although the optimal weekly dose in the phase II study was 150mg/m.
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